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Our laboratory focuses its activities on the study of drugs (with special emphasis on anti-infective drugs) in a broad context.

The Team
consists of approx. 20 scientists, 4 technicians, and students


Research activities include:
  • Laboratory Research examines the interactions between antiinfective agents (mainly antibiotics) and eucaryotic cells within a context of cellular and molecular pharmacology and toxicology. Disciplines and methodologies used span from Biophysics and Cellular and Molecular Biology to Morphology and Animal Trials.  New, original molecules are either designed and synthesized or screened from natural sources
    .
  • Clinical Research aims at improving the use of antibiotics in the hospital set-up, based usually but not exclusively on pharmacodynamic considerations and starting from original experimental research in this area.  

    Note: Clinical Pharmacy, launched in 2001, is now organized as the Centre for Clinical Pharmacy (with a research group part of the Louvain Drug Research Institute)

Educational activities are undertaken within the context of the the Information Center on Infective Pathology and Anti-infective Chemotherapy, the Séminaire de Pathologie Infectieuse, the Belgian Antibiotic Policy Coordination Committee, the Belgian Society of Infectiology and Clinical Microbiology, and the International society for Antiinfective Pharmacology.

Contract-based research and educational activities are undertaken in each of these areas.



Science and Education
Contact and Relations


Main Themes of research

  1. Laboratory research

  • Clinical research

  • Clinical Pharmacy (launched in 2001)
    This activity has now evolved on its own, while maintaining strong links with our researcxh group
    Please, visit the WEB site of the
    Centre for Clinical Pharmacy (CFCL)



  • Expertise (available for contract-based activities) 
    • Laboratory  research
      • in vitro studies of drug-membrane interactions (biophysical and biochemical studies)
      • in vitro (cellular models) of antibiotic activity in intracellular infections (cellular pharmacokinetics and pharmacodynamics)
      • in vitro (cellular and a-cellular models) and in vivo (animal models) evaluation of antibiotic safety
      • rational design and synthesis of new antimicrobials
      • phenotypic and genotypic methods for the search of resistance by efflux in human pathogens

    • Clinical trials and assessment of benefit/risk ratio of antibiotics: 
      • pharmacodynamics and toxicodynamics-based new approaches for antibiotic dosing
      • new drug trials
      • litterature and database analysis (for registration and regulatory affairs purposes)

    • Educational activities
      • workshop and conferences on pharmacodynamics, resistance and appropriate choice of antiinfective agents
      • interactive sessions about the appropriate use of drugs for medical and pharmaceutical audiences
      • private courses for Industry


    Publications (asbtracts and full text available for the most recents)
    • list of all papers by categories 
    • original contributions, reviews, books, chapter of books, proceedings, PhD and Master degree dissertations, educational papers, published abstracts 
    • indexed search 
    • by author, year, journal, type of publication, keywords


    Educational activities


    Contacts:


    Address and  access:

    Location:

    The Unit is located on the campus of the Health Sciences Sector (Secteur des Sciences de la Santé) of the Catholic University of Louvain (Université catholique de Louvain) in Brussels (Woluwé Saint-Lambert; approx. 10km [7 mi.] from the city center). Access: Directions and Access Maps (car - train and subway - plane) - Find us on Google maps (will open a new tab)

    Team (Last update: May, 29, 2021) -- see photo of most of the members of the lab during our last social activities (visiting Bruges on July 4, 2007; Pairi Daiza on July 8, 2013; celebrating 40 years of work of MC Cambier in November 2015: thanking Marie-Claire Cambier for her work in the lab during 42 years; Pairi Daiza in May 2018; visit of the chocolate museum in December 2018 ; visit in Namur (Brasserie de la Houppe) in July 2019; and on Christmas parties (2007; BLUENILEMILLS Regal Embroidery Sheet Set, Gift Box, Twin XL, Ivo; 2009; 2010; 2011; 2012-2013 ; 2013 ; 2014 ; 2015; 2016 ; Herth+Buss Jakoparts J5642003 Sensor, throttle position; 2018)
     

    Phone numbers: if calling from

    • within the Health Science Sector (Faculties and Cliniques universitaires St-Luc at Woluwé-St-Lambert): dial 4 and then only the last 4 digits (ex.: 4-7370)
    • from the University main campus (Louvain-la-Neuve) or the campuses of St-Gilles and Mons: dial 774 and the last 4 digits (ex.: 774-7370)
    • from anywhere else in Belgium: dial 02 followed by the 7 digits number shown hereunder (thus 9 digits in total; ex.: 02-7647370)
    • from outside Belgium: dial your International Access Code (IAC) followed by 32 (Belgium), 2 (Brussels) and the the 7 digits number shown hereunder (thus 10 digits in total after your IAC)
      (example: IAC-32-2-7647370)
    E-mails: as from July 2007, the University uses the <first_name.last_name@uclouvain.be> addressing system, which is in use for all addresses created since then.
    However, all former addresses using <name@facm.ucl.ac.be> that were created before July 2007 are still working and can be used.

    Scientific Staff

    Senior investigators (click on the name to get a C.V.)

     
     
     

    Junior Investigators

    Gert-Jan Wijnant, Belgium (PhD)
    764.73.71
    <gert-jan.wijnant@uclouvain.be>
    research topic: reviving old antibibiotics
    general theme: Clinical evaluation of new approaches in antibiotic dosing
    support: Beware (région Wallonne)

    Negar Mozaheb, Iran (PhD)
    764.73.76
    <negar.mozaheb@uclouvain.be>

    research topic: Influence of amphiphilic aminogycoside derivatives on bacterial membrane properties
    general theme: drug-membrane interactions
    support: Fonds National de la Recherche Scientifique

    Audrey Comein, MBiomedSc,Belgium
    (PhD in Biomedical and Pharmaceutical Sciences)
    764.72.75
    <audrey.comein@uclouvain.be>

    research topic: intracellular life of Pseudomonas aeruginosa
    general theme:
    Chemotherapy of intracellular infection
    support:
    Université catholique de Louvain
    Steven De Soir, MBiomedSc,Belgium
    (PhD in Biomedical and Pharmaceutical Sciences)
    764.73.76
    <steven.desoir@uclouvain.be>
    research topic: Phages and mixed species biofilms in the context of orthopedic infections
    general theme: Antibiotic activity against biofilms
    Support: Innoviris
    Mandeep Kaur, MSc, India
    (PhD in Biomedical and Pharmaceutical Sciences)
    764.73.56
    <M.kaur@uclouvain.be>
    research topic: Influence of amphiphilic aminogycoside derivatives on bacterial membrane properties
    general theme: drug-membrane interactions
    support: Université catholique de Louvain (actions de recherches concertées)
    Perrin Ngougni Pokem, Pharm, Cameroon
    (PhD in
    Biomedical and Pharmaceutical Sciences)

    764.72.25
    <perrin.ngougni@uclouvain.be>
    research topic: optimisation of antibiotic usage based on therapeutic monitoring approaches
    general theme:
    Clinical evaluation of new approaches in antibiotic dosing and Clinical Pharmacy
    support:
    Université catholique de Louvain

    Hervé Poilvache, MD, Belgium
    (PhD in Medical Sciences)
    764.73.56
    <herve.poilvache@uclouvain.be>

    research topic: improving diagnostic and treatment of orthopedic infections
    general theme:
    Antibiotic activity against biofilms
    support:
    Fondation Saint Luc and Fonds pour la Recherche dans l'Industrie et l'Agriculture (FRIA)

    Albert Ruiz Sorribas, MMicrobiology, Spain
    (PhD in Biomedical and Pharmaceutical Sciences)
    764.73.56
    <albert.ruiz@uclouvain.be>

    research topic: mixed species biofilms in the context of orthopedic infections
    general theme: Antibiotic activity against biofilms
    Support: Fonds spéciaux de Recherches, UCL (FSR) and Région wallonne (Cotton Rye Outfitters Seminole Lead Macon Pillow, 12, Tan/Ivor)

    Hélène Thirot, Pharm, Belgium
    (PhD in Biomedical and Pharmaceutical Sciences)

    764.73.75
    <helene.thirot@uclouvain.be>
    research topic: off label use of antibiotics: associated risk of toxicity and of selection of resistance
    general theme:
    Clinical evaluation of new approaches in antibiotic dosing and Clinical Pharmacy
    support:
    Université catholique de Louvain
    Gang Wang, Pharm, China
    (PhD in Biomedical and PharmaceuticalSciences)

    764.73.56
    <gang.wang@uclouvain.be>
    research topic: role of active efflux in persistent infections and pharmacological modulation
    general theme:
    Chemotherapy of intracellular infection and Antibiotic activity against biofilms
    support: China Scholarship Council

    Zhifen Wang, Pharm, China
    (PhD in Biomedical and Pharmaceutical Sciences)

    764.73.76
    <zhifen.wang@uclouvain.be>

    research topic: antibiotic activity against biofilms in the context of cystic fibrosis
    general theme:
    Antibiotic activity against biofilms
    support: China Scholarship Council

    Laetitia Fontaine, Belgium (PhD)
    764.72.37
    <laetitia.fontaine@uclouvain.be>

    research topic: novel strategies against biofilms
    general theme: Antibiotic activity against biofilms
    support: Région wallonne (in connection with OneLife)

    Tamara Milosevic, Pharm, Serbia (PhD)
    764.73.71
    <tamara.milosevic@uclouvain.be>

    research topic: cellular pharmacokinetics and toxicity of oxazolidinones
    general theme: Cellular toxicity induced by antibiotics and other drugs

    Vasileios Yfantis (full-time technician)
    764.73.76
    <vasileios.yfantis@uclouvain.be>

    research topic: novel strategies against biofilms
    general theme: Antibiotic activity against biofilms
    support: Région wallonne (in connection with OneLife)

     

        Arthur Balcaen (student in pharmacy) research topic: intracellular infection and persistence
    general theme:
    Chemotherapy of intracellular infection
        Adel Laghouati (student in pharmacy) research topic: innovative strategies against Staphylococcal biofilms
    general theme: Antibiotic activity against biofilms
        Raphaël Modard (student in pharmacy) research topic: Influence of drugs on bacterial membrane properties
    general theme: drug-membrane interactions
        Hortence Parée (master in biomedical sciences) research topic: Phages and biofilms
    general theme: Antibiotic activity against biofilms
        Paria Rassouli (student in pharmacy)

    research topic: Influence of amphiphilic aminogycoside derivatives on bacterial membrane properties
    general theme: drug-membrane interactions

    Technical and Administrative Staff

    Murielle Callier (part-time secretary)
    <murielle.callier@uclouvain.be>
    main activities: accounts, administrative tasks
    support: FP7 program of European Union

    Alix Mangin (full-time technician)
    764.72.25
    <alix.mangin@uclouvain.be>

    main activities: HPLC, microbiology
    support: Région wallonne (Parker A6FA7-MG-pk5 Push-to-Connect All Plastic FDA Compliant Fi)

    Virginie Mohymont (full-time technician)
    764.73.70
    <virginie.mohymont@uclouvain.be>

    main activities: secretarial and administrative tasks; microbiology,cell culture, biochemistry and molecular biology
    support: Université catholique de Louvain

    Romain Tricot (full-time technician)
    764.73.70
    <romain.tricot@uclouvain.be>

    main activities: microbiology, biochemistry, cell culture
    support: Université catholique de Louvain


    Former Staff Members, Post-doctoral fellows,Visiting Scientists, Doctoral fellows, Non-doctoral fellows, and Students

    by chronological order of joining the laboratory and with the following information by order: Name, degree when joining the Unit, Country/State, period of stay, position(s) held, main and/or final degree earned if any, source(s) of financing

    Former staff members

    Post-doctoral fellows

    Visiting scientits

    Doctoral fellows

    Non-doctoral fellows

    Students

     

    Former Technical and Administrative Staff

    by chronological order of leaving the laboratory

      Francine Andries Epse Renoird
    (1st Head Technician)
    main activities: biochemistry, electron microscopy, training of new fellows, accounting

    started: 1970
    left: 2006

      Olga Meert (1st Technician) main activities: general maintenance

    started: 1991
    left:
    2007

      Jonathan Gesels (technician) main activities: serotyping by molecular biology techniques started: 2009
    left:
    2010
      Martial Vergauwen (technician)

    main techniques: biophysics, biochemistry, cell fractionation

    started: 2004
    left:
    2011
      Charlotte Misson (technician) main techniques: biochemistry, microbiology started: 2006
    left:
    2011
      Nathalie Couwenbergh (technician) main techniques: HPLC, microbiology, molecular biology started: 2007
    left: 2012
      Ozlem Misir (technician) main techniques: biophysics, biochemistry

    started: 2010
    left: 2012

      Julie Maron ( technician) main techniques: biophysics, biochemistry started: 2013
    left: 2015
      Marie-Claire Cambier (1st Head Technician) main techniques: cell culture, microbiology, biochemistry started: 1974
    left: 2017
      Pierre Muller (technician) main techniques: HPLC, microbiology, molecular biology started: 2012
    left: 2017
      Adrien Chaniotacos (technician) main techniques: microbiology started: 2019
    left: 2019
      Katia Santos Saial main techniques: cell culture, microbiology, biochemistry started: 2011
    left: 2020
      Vasileios Yfantis main techniques: microbiology

    started: 2015
    left: 2020


    Financing


    Special Events

    (by chronological order since 1997)